"In cases where there is even the slightest doubt, and especially in women at increased risk, the obvious choice is MRI. Our study clearly shows the superiority of magnetic resonance imaging over mammography and breast ultrasound examinations," says Thomas Helbich, who led the study with Christopher Riedl. "The superiority of MRI is also completely independent of the patient's age, gene mutation status and breast density."
In 559 women at increased risk, a total of 1,365 screening examinations were carried out. There was one clear "winner": 90 per cent of all breast cancers can be clearly detected by MRI. The combination of MRI and mammography increased the detection rate by just five per cent. None of the cancers were detected by ultrasound alone. The results were similar for non-invasive cancers and for benign breast lesions.
"An MRI scan carried out once a year is therefore the only alternative for high-risk patients who have a strong family history of breast cancer to the surgical removal of the breast and ovaries," says Helbich. "This is by no means 'over-diagnosis', but rather a necessity. Around 13,000 women in Austria are still at increased risk of breast cancer."
Call in favour of MRI and "Southern European ratios"
The results of the study, says the MedUni Vienna expert, should encourage the increased use of MRI for breast screening too. Says Helbich: "In light of these results, it is our duty to make women more aware of the fact that the use of mammography and ultrasound cannot detect all types of cancer. MRI really is the method to be recommended."
Currently Austria has 15 MRI scanners per million inhabitants - putting the country above the EU average (10 scanners / million inhabitants). If MRI is to be used more frequently, Italian or Greek ratios would be better: in these countries, there are 24 and 23 MRI scanners per million inhabitants respectively.
Service: Journal of Clinical Oncology
„Triple-Modality Screening Trial for Familial Breast Cancer Underlines the Importance of Magnetic Resonance Imaging and Questions the Role of Mammography and Ultrasound
Regardless of Patient Mutation Status, Age, and Breast Density.“ Christopher C. Riedl, Nikolaus Luft, Clemens Bernhart, Michael Weber, Maria Bernathova, Muy-Kheng M. Tea, Margaretha Rudas, Christian F. Singer, and Thomas H. Helbich. J Clin Oncol. 2015 Feb 23. pii: JCO.2014.56.8626. jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.56.8626.
An online tool has been developed at the MedUni Vienna for the early detection of breast cancer risk. The link can be found here:
The study received financial support from the Austrian National Bank's anniversary fund.
Five research clusters at the MedUni Vienna
A total of five research clusters have been set up at the MedUni Vienna in which the MedUni Vienna is increasing its focus in the fields of fundamental and clinical research. The research clusters include medical imaging, cancer research / oncology, cardiovascular medicine, medical neurosciences and immunology. The present work falls in terms of its content within the remit of medical imaging.