ARCHIMEDlife: New cut-offs for lysosomal enzyme activities

We are happy to inform you that we have introduced a new diagnostic assay for the analysis of lysosomal enzyme activities from Dried Blood Spots using Clinical Mass Spectrometry. This new assay will enable us faster turn-around times.
The assay was fully validated, and approved and accredited according to ISO 15189.
Please note that the cut-offs will change as follows:


old cut-off



a-Galactosidase A for Fabry disease

acid a-1,4-Glucosidase for Pompe disease

acid Sphingomyelinase for Niemann-Pick A/B disease (ASMD)

ß-Glucocerebrosidase for Gaucher disease


>1.2 µmol/L/h

>3.3 µmol/L/h

>0.9 µmol/L/h


>2.5 µmol/L/h


>2.8 µmol/L/h

>2.0 µmol/L/h

>1.2 µmol/L/h


>1.5 µmol/L/h


General information for you: The measurement of an enzyme activity and its cut-off is depending on substrates used, incubation temperature and time, and may differ from assay to assay, and lab to lab.

Please do not hesitate to contact us: info(at)

Your ARCHIMED Life Science Team.

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