Vetmeduni Vienna: Comparing food allergies: Animals and humans may have more in common than you think

People are not the only ones suffering from the symptoms and problems of food intolerance and allergies. Other mammals, such as cats, dogs and horses, are affected as well. The Messerli Research Institute, a cooperation between the University of Veterinary Medicine Vienna and the Medical University of Vienna, has now condensed the knowledge about human and animal food allergies and intolerances into a new European position paper. The paper highlights the strong similarities in animal and human symptoms and triggers of adverse food reactions. More importantly, the publication stresses the need for more comparative studies on the mechanisms and the diagnosis of food intolerance, and on formulating adequate measures.

Diarrhea after a glass of milk, an itchy palate after eating apples, swelling in the face after consuming chicken eggs or a severe asthma attack due to peanut dust are all signs of a food intolerance or allergy. But these symptoms are not limited to us humans, because other mammals such as dogs, cats and horses may exhibit similar symptoms after feeding. The number of pets affected by food allergies and intolerances has even converged with that of humans.

A working group of the European Academy of Allergy and Clinical Immunology (EAACI) focuses on exactly this issue. The group has recently published a position paper that sums up food intolerances and allergies in both animals and humans, laying bare knowledge gaps.

Symptoms and triggers of intolerances and allergies overlap
"Not only humans but basically all mammals are susceptible to developing allergies, as their immune system is capable of producing immunoglobulin E," says lead author Isabella Pali-Schöll. Normally, these special antibodies help defend parasites or viruses. At the same time, they are also responsible for type I allergy symptoms, which are the most well-known and immedately-occurring symptoms and include hay fever, allergic asthma and anaphylactic shock. In the field of nutrition, there are also very common non-immunologic forms of food intolerance.
The position paper, primarily penned by Pali-Schöll and Erika Jensen-Jarolim from the interdisciplinary Messerli Research Institute of the University of Veterinary Medicine Vienna and of the Medical University of Vienna, shows that the symptoms of food intolerance are similar in both animals and humans. In the case of dogs, cats or horses, however, the adverse reactions mostly affect the skin, followed by the gastrointestinal tract. "Asthma or severe shock reactions have rarely been observed in animals," notes Pali-Schöll.

There are even overlaps among the triggers of immune response to certain foods and ingredients. Pets may suffer from both lactose intolerance and outright milk protein allergies. Some mammals are also liable to allergic reactions from certain proteins in wheat, soy, peanuts, tree nuts, fish, eggs and meat.

Molecular allergy diagnostics for animals is still underdeveloped
Precise knowledge about the active molecules of the allergens helps assess the risks of severe reactions, especially with food allergies. Many of these allergenic molecules that affect humans have been identified and are already used in diagnostics, such as the so-called allergen microchip test. As far as animals are concerned, there is still a big need for research.

Similarly, a precise and comprehensive diagnosis is essential for establishing adequate measures against food intolerance. But many mechanisms and triggers for animals have not been sufficiently researched, in part because some test samples or substances are not even available.

Avoiding allergens is the best animals and people can do for now
A so-called elimination diet is the prerequisite for correctly diagnosing animals and humans. This regimen consists of removing all sources of protein from an animal's diet. "During this period of diagnosis, the animal will be fed homemade food or diet food prescribed by a veterinarian. Only then, and if there have not been any dangerous allergic reactions before, can 'normal' food be gradually reintroduced," advises nutrition scientist Pali-Schöll. This diagnostic procedure allows the allergen-free diet to be tailored to the respective food intolerance, while avoiding unnecessary restrictions.

A thorough comparison of adverse food reactions in humans and animals offers insight into the risk factors for the development of the condition, and can thus lead to improved recommendations for the prevention and treatment of adverse food reactions in animals and humans.
At the moment there are no therapies for humans and animals, but many new variants of immunotherapy have entered trial phase. "As for the so-called sublingual and epicutaneous immunotherapy, which is treatment under the tongue or on the skin, respectively, the first few trial phases have already achieved some success. But it will take several more years for any products to see market launch and standard application," says Pali-Schöll.

The European position paper "Comparing immediate-type food allergy in humans and companion animals – revealing unmet needs” by Pali-Schöll I, De Lucia M, Jackson H, Janda J, Mueller RS and Jensen-Jarolim E has been published in the trade journal Allergy.

About Messerli Research Institute
The Messerli Research Institute was founded in 2010 with support from the Messerli Foundation (Sörenberg, Switzerland) under the management of the University of Veterinary Medicine, Vienna in cooperation with the Medical University of Vienna and the University of Vienna. The research is devoted to the interaction between humans and animals, as well as its theoretical principles in animal cognition and behavior, comparative medicine and ethics. Its work is characterized by its broad interdisciplinary approach (biology, human medicine, veterinary medicine, philosophy, psychology, law) and strong international focus.

About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,300 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms.

Press contact
Scientific Contact:
Isabella Pali-Schöll
Comparative Medicine
Messerli Research Institute
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
Tel: +43 (0)1 25077-2659
Email: isabella.pali(at)

Erika Jensen-Jarolim
Comparative Medicine
Messerli Research Institute
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
Tel: +43(0)1 25077-2659
M +43 664 832 6818
Email: erika.jensen-jarolim(at)

Released by:
Georg Mair
Science Communication / Corporate Communications
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
Tel: +43 (0)1 25077-1165
Email: georg.mair(at)

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