"We will concentrate mainly on the fundamental question of how chromosomes are correctly transmitted to daughter cells during eukaryotic cell divisions", says Franz Klein, coordinator of the SFB project. A special focus will be devoted to meiosis, a specialized division essential for gamete formation, which requires genetic recombination between maternal and paternal chromosomes for correct chromosome segregation in most organisms, in addition to the mechanisms operating in mitosis. In various organisms the role of specialized chromosomal domains will be addressed, in particular the role of the kinetochore and its interaction with the spindle apparatus in mitosis and meiosis, as well as the role of the diversification of chromosomes into loop and axis-associated domains. The SFB contains two technological platforms, Mass Spectrometry and Chip on Chip. These discovery tools are expected to deliver novel chromosome components and to map their positions. Members of the SFB: MFPL (Gustav Ammerer, Juraj Gregan, Peter Schlögelhofer), IMP (Karl Mechtler, Jan Michael Peters, Stefan Westermann). Coordination: Franz Klein
SFB grant awarded to MFPL and IMP consortium: Chromosome Dynamics- Unravelling the Function of Chromosomal ...
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