An international study group including MedUni Vienna has conducted a so-called umbrella review. This relatively new statistical tool is an analysis of meta-analyses representing the highest level of evidence. The umbrella review analysed the results of 20 meta-analyses, which in turn include a total of 3,200 studies on the subject of health outcomes associated with HIV. The results were published in the specialist journal "Clinical Infectious Diseases".
While the meta-analyses identified a total of 55 outcomes that are associated with HIV infection, the superordinate umbrella review identified 37 of these health outcomes as having significant associations and 8 of them a having suggestive and highly suggestive evidence of associations with HIV. These are COPD (Chronic Obstructive Pulmonary Disease), dyspnoea, cough, anaemia, maternal sepsis, pregnancy -related mortality, as well as bone fractures and ischaemic heart disease.
"People living with HIV have a significantly higher risk of suffering from these diseases or symptoms during the course of their lives," explains lead author Igor Grabovac from MedUni Vienna's Department of Social and Preventive Medicine. The study was a collaboration between MedUni Vienna and researchers from Austria, Italy, Spain, Canada and the UK.
In Austria, around 98% of people living with HIV have their condition managed by drugs. Despite their good life expectancy, they have more chronic diseases than people without HIV. "Further research is needed to find out why people living with HIV also have additional health problems," explains Igor Grabovac, "possible reasons are the side-effects of the drugs, lifestyle factors or the virus itself, which causes faster cell ageing due to chronic infection within the body."
The results of this study offer interesting new hypotheses for further clinical studies and basic research and provide treating doctors with a list of the health risks facing HIV patients.
Service: Clinical Infectious Diseases
„HIV infection and diverse physical health outcomes: an umbrella review of meta-analyses of observational studies” Igor Grabovac, Nicola Veronese, Sinisa Stefanac, Sandra Haider, Sarah E Jackson, Ai Koyanagi, Michael Meilinger, Brendon Stubbs, Joseph Firth, Pinar Soysal, Francesco Di Gennaro, Jacopo Demurtas, Daragh T McDermott, Adam D Abbs, Lin Yang, Lee SmithClinical Infectious Diseases, 11 August 2019. https://doi.org/10.1093/cid/ciz539.