Heart failure is one of the most frequent diseases in western countries. Among other, three medication groups (Angiotensin converting enzyme (ACE)-inhibitors, Betablockers and Angiotensin receptor blockers (ARB)), with clear guidelines on prescription practice, are used for the treatment. A joint study of the Medical University of Vienna and experts of the study group for heart failure of the Austrian Cardiology Society under the guidance of Thomas Stefenelli examined the dosages prescribed to outpatients based on the national Austrian heart failure registry (3,737 patient data).
During an observation period of twelve months, only a limited part of the patients with chronic systolic heart failure received the recommended maximal dosages. Most patients were distinctly below the recommended optimal therapeutic dosage. This became particularly clear within a substance class with different numerical maximum dosages to achieve the same therapeutic effect. Thus, medication with a higher target dosage in absolute numbers (e.g. Betablocker 10mg vs 200mg) were prescribed at a significantly lower dosage than recommended, while the probability that the maximum target dosage was prescribed was considerably greater in medication with a lower numerical target dosage.
Martin Hülsmann, Cardiologist at the Medical University of Vienna, who contributed substantially to the study together with her colleague Henrike Arfsten, considers a unconscious cognitive bias as the reason: "We find an unconscious fear of overdosing and a fear of side effects of medication among our colleagues, which continues to exists also in evidence-based medicine. This is particularly relevant the greater the target dosage of a pharmaceutical product and prevents the administration of the dosage tested as optimal in pivotal studies."
Hülsmann assumes that this overly cautious behaviour is not a particular problem of cardiological treatments, but that this overcautiousness in the dosage of prescription also exists in other medical sectors. "We would like to see further studies which trace this bias also in other medical specialities and diseases."
As a first step, the authors of the study therefore suggest to check these results in larger patient groups and other disease entities. If the results are confirmed, the authors recommend to supplement the guideline-recommendations based on milligram dosages with guidelines based on equivalence dosages. Prescription of the correct and tested medication dosage is important to achieve the intended therapeutic effect and to provide patients with the best possible quality of life, in this case relating to heart failure.
Service: „Annals of Internal Medicine“
Prescription Bias in the Treatment of Chronic Systolic Heart Failure
Henrike Arfsten, Georg Goliasch, Noemi Pavo, Hanno Ulmer, Martin Hülsmann, Thomas Stefenelli; „Annals of Internal Medicine“, publ. 1. October 2019
Published: Ann Intern Med. 2019. DOI: 10.7326/M19-0476.