The findings have been published advanced online in the journal Nature Chemical Biology: The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity. Georg E Winter, Branka Radic, Cristina Mayor-Ruiz, Vincent A Blomen, Claudia Trefzer, Richard K Kandasamy, Kilian V M Huber, Manuela Gridling, Doris Chen, Thorsten Klampfl, Robert Kralovics, Stefan Kubicek, Oscar Fernandez-Capetillo, Thijn R Brummelkamp, Giulio Superti-Furga. Nature Chemical Biology. doi:10.1038/nchembio.1590. SLC are the neglected gates that regulate access to biological systems to chemistry, or of organisms to the environment. CeMM is dedicated to mount a large interdisciplinary effort involving several laboratories to try to crack the “code” of the transport and regulation specificity. This will take several years but will allow to have better targeted drugs, that are safer because they know where they go, and to understand the relationship between drugs and nutrition.
CeMM: The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity
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