Bornaviruses cause a lethal form of encephalitis, called Borna disease, among horses and sheep. To date there have been only a few reported cases in Austria. Recently, however, four horses were afflicted in the same area of Upper Austria within just two years. Tests conducted on local shrews, the only known reservoir host for the virus, confirmed the suspicion of a local viral reservoir. A large proportion of the small mammals investigated by the researchers from Vetmeduni Vienna tested positive for Bornaviruses, which were revealed to be genetically distinct from strains found in neighbouring regions such as Bavaria. The study, conducted in cooperation with the Austrian Agency for Health and Food Safety (AGES) and local veterinarians, and published in the journal Emerging Microbes & Infections, documents this rare outbreak of Borna disease in a new endemic area in Austria.
The islets of Langerhans in the human pancreas produce and release insulin to regulate blood glucose levels. Insulin, which is specifically produced in -cells, serves to prompt cells to take up glucose circulating in blood. Thus, insulin release lowers the level of glucose in blood. In diabetes, this cycle is disrupted by the premature death of -cells. Working with an international team of researchers, Katarzyna Malenczyk from the Department of Molecular Neurosciences at MedUni Vienna's Center for Brain Research showed in the study published in the EMBO Journal today that the loss of a key protein, secretagogin, triggers the death of -cells and, conversely, that these cells can be protected by increasing the amount of this protein in those suffering from diabetes.
AOP Orphan Pharmaceuticals AG (AOP Orphan) today announced that RAPIBLOC® (Rapibloc, 300 mg powder for solution for infusion) will as of June 19th be first commercialized by its distribution partner Amomed Pharma GmbH (Amomed) and thereby be available to treat patients in Germany and Austria followed by selected Central European countries. Later this year the product will furthermore be launched in Scandinavia. Launch preparations in other European countries are ongoing.
Gene transfer is seen as a hopeful therapy for Alzheimer’s and Parkinson’s patients. The approach involves using harmless laboratory-produced viruses to introduce important genes into the brain cells. In a study on mice, a team of researchers from Vetmeduni Vienna for the first time investigated how far these viruses spread in the brain and which cells they infect. Some of the artificial viruses travelled from the injection site in the brain as far as the olfactory bulb or the cerebellum and infected not only neurons but also other cells. The results, which were published in the journal Histochemistry and Cell Biology, could help to improve the selection of suitable viral “gene transporters” for custom therapies using gene transfer.
Collaborating with four partners, piur imaging will develop the 2nd generation of PIUR tUS. This is a new device for tomographic 3D ultrasound allowing safe and more cost effective vascular diagnosis and treatment planning.
Diagenode, a leading global provider for complete solutions for sample preparation and epigenetics research, has licensed a new technology specific for ChIP-sequencing from the CeMM for low input samples.
A new study from the ABCSG (Austrian Breast & Colorectal Cancer Study Group) indicates that women suffering from metastasised breast cancer do not benefit from surgery performed prior to drug treatment. This could cause a paradigm shift in treatment of the disease. The multi-centre trial, conducted under the direction of Florian Fitzal, was presented this weekend at the ASCO meeting, one of the most important international cancer conferences. Florian Fitzal is Head of Breast Surgery at the Department of Surgery of MedUni Vienna/Vienna General Hospital and one of the two deputy heads of the Breast Health Center at the Comprehensive Cancer Centre (CCC) of MedUni Vienna and Vienna General Hospital.
With 121 successfully tested profiles and actors, Tiani Spirit wins 1st place at the IHE Connectathon Venice 2017. This almost twice as much as the second place. Recently, the company also has announced the foundation of a subsidiary in Germany.